Comparison of In-Hospital Outcome of Acute ST Elevation Myocardial Infarction in Patients with versus without Diabetes Mellitus

Background: Diabetes mellitus (DM) is a stronger risk factor for coronary artery disease (CAD) and is associated with mortality and morbidity of cardiovascular disease. The in-hospital outcome in diabetic patients with acute ST elevation myocardial infarction (STEMI) is less known. The aim of this study is to evaluate in-hospital outcome of acute STEMI in patients with diabetes mellitus. Methods: The patients with acute STEMI between November 2007 to June 2009 were enrolled, the traditional risk factors for CAD, the inflammatory marker and coronary angiographic results were recorded. The in-hospital outcome of patients with and without DM were compared. Results: Total 239 patients with acute STEMI were enrolled. Of those, 94 (39%) were diabetic and 145 (61%) were non-diabetic patients. Older, multi-vessel diseases, poor renal function, higher killip class and the higher inflammatory marker level were associated with in-hospital mortality in patients with STEMI. In-hospital mortality was higher in diabetic than non-diabetic patients (23.4% vs. 7.6%, p = 0.001). Previous hypertension, cerebral vascular disease were more frequent in diabetic than in non-diabetic patients. Diabetic patients also demonstrated higher creatinine level than non-diabetic patients (creatinine: 2.14 1.54 vs. 1.34 0.99 mg/dl, p < 0.001). Conclusion: This study suggests that in diabetic patients with acute STEMI, in-hospital mortality rate is higher than in non-diabetic patients. The aggressive treatment early in the course of diabetic patients with acute STEMI is important.